Rebranding Repurposing: a Polypharmacological Perspective
“Drug repurposing doesn’t work. We’ve all tried it and it doesn’t work.”
Posts about
Polypharmacology
Drug Discovery on the Dark Proteome - Delivering Tomorrow's Medicines
The role of a given protein(s) to a specific disease or indication is a fundamental aspect of drug...
Flipping the (Drug Discovery) Problem on its Head with Polypharmacology
For context: medicines have traditionally been designed to target a single protein with high...
Polypharmacology - setting the foundation for successful drug
Drugs are amazing. I can’t help but marvel at how a small collection of atoms carefully arranged in...
What's the fuss behind polypharmacology & multi-targeted drug design?
Originally posted on LinkedIn: https://bit.ly/3bpyKpG
It is well understood that while the common...
The Advent of In Silico Polypharmacology
In February 2017, we released a special perspective on the history of computational drug...
Polypharmacology: An underutilized paradigm in drug discovery
In the 1950s, Chemi Grünenthal marketed a small molecule drug to relieve symptoms of nausea and...